Please use this identifier to cite or link to this item: http://repository.ush.edu.sd:8080/xmlui/handle/123456789/694
Title: RARE CASE OF INTRACTABLE SEIZURE WITH POLYPHARMACY DUE TO TUBEROUS SCLEROSIS
Authors: Motwakil, Imam Awadelkareim Imam
Keywords: Tuberous
Sclerosis
Tuberous Sclerosis
polypharmacy
Intractable seizure
seizure
Intractable
Issue Date: 7-Jun-2019
Publisher: European Journal of Biomedical and European Journal of Biomedical AND Pharmaceutical sciences
Series/Report no.: ejbps, 2019, Volume 6,;Issue 6, 368-374
Abstract: Tuberous Sclerosis exhibits an autosomal dominant inheritance pattern, with a high spontaneous mutation rate. The TSC2 gene was named tuberin. The highest levels of tuberin are found in adult human brain, heart, and kidney; tuberin also has been localized to arterioles of kidney, skin, and heart, as well as to pyramidal neurons and cerebellar Purkinje cells. Complications of neurological involvement are the most common causes of mortality and morbidity. These are due chiefly to intractable epilepsy, status epilepticus, and subependymal giant cell astrocytoma (SEGA) with associated hydrocephalus. We report a case a 33 years old sudanese female with intractable seizure in spite of polypharmacy with skin, renal, and cerebral manifestations of tuberous sclerosis.
Description: Tuberous Sclerosis exhibits an autosomal dominant inheritance pattern, with a high spontaneous mutation rate. The TSC2 gene was named tuberin. The highest levels of tuberin are found in adult human brain, heart, and kidney; tuberin also has been localized to arterioles of kidney, skin, and heart, as well as to pyramidal neurons and cerebellar Purkinje cells. Complications of neurological involvement are the most common causes of mortality and morbidity. These are due chiefly to intractable epilepsy, status epilepticus, and subependymal giant cell astrocytoma (SEGA) with associated hydrocephalus. We report a case a 33 years old sudanese female with intractable seizure in spite of polypharmacy with skin, renal, and cerebral manifestations of tuberous sclerosis.
URI: http://hdl.handle.net/123456789/694
ISSN: 2349-8870
Appears in Collections:Researches and Scientific Papers البحوث والأوراق العلمية

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