Detection of Amyloid among Adenocarcinoma Tissues in Shendi Town 2021

Abstract

Abstract Background: Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when an abnormal protein, called amyloid, builds up in your organs and interferes with their normal function. Amyloid isn't normally found in the body, but it can be formed from several different types of protein. Organs that may be affected include the heart, kidneys, liver, spleen, nervous system and digestive tract. Amyloid tumor of the breast, first reported in 1973, is a rare disease, with only six cases reported in Japan to date. Some varieties of amyloidosis occur in association with other diseases. This study aimed to detect amyloid in adenocarcinoma tissues. Materials and methods: This was a descriptive cross sectional study conducted in Shendi town during the period from September 2021 to January 2022. A total of 240 tissues were enrolled in this study, 200 of them were adenocarcinoma tissues included as case group and the remainder 40 benign tissues were included as control group. Socio demographic and samples data were collected by using questionnaire. Amyloid was detected using Congo red technique. Results: Amyloid was detected in 182 cases (91%) of cancerous tissues. Benign tissue sections were showed positive amyloid in 6 cases (15%). Conclusion: There was extreme amyloid expression in adenocarcinoma tissues. The amyloid density increased with late stage