Immunohistochemical Based Detection of HPV in Gastric Cancer among Sudanese Patient

Abstract

Screening for viruses is an essential step in the continuum of research that is expected to lead to new treatment strategies in patients with virus-positive tumors. This study aimed to demonstrate the presence of human papilloma virus (HPV) in gastric tumors The study involved 30 formalin fixed paraffin embedded blocks from patients with gastric tumors, collected during January 2014 and October2015.in histopathology departments of Omdurman teaching hospital, Khartoum, Sudan. The presence of HPV was determined using immunohistochemistry Among the 30 patients, 20 male (66.7%) and 10 female (33.3%) with (2:1) male: female ratio, only two samples (6.7%) were positive for HPV, while 28(93.3%) were negative. the pathogenic causative role of HPV infection in Sudanese patients with gastric cancer was not established.