Effects of Antiepileptic Drug (Valporic Acid) on Complete Blood Count Parameters among Patients Attending Eltigain Elmahi Neurological and Psychological Hospital-Khartoum Stata -Sudan

Abstract

I Acknowledgment Thanks to ALLAH for giving me strength to achieve this research though a tough community base, which reminded me to be grateful of having well fair and full appreciation to that. Thanks to Dr. Hussam for guiding and enlightening though the path of this work Thanks to who worked behind sense and never get enough thanks…….. Thanks to everyone who did not got mentioned, not intentionallyIV Abstract Background Epilepsy, affecting 5-10 per 1000 population, is characterized by the occurrence of at least two unprovoked seizures brought about by abnormal discharge of cortical neurons. The lifetime risk of developing psychiatric disorder with epilepsy is extremely high with such individuals having greater psychiatric co-morbidity when compared to the general population. Valporic acid is a drug used as mood stabilizer and ant convulsion episodes, it has been given indifferent doses prescribed by the physician and most of time as anti-psychological drugs used for life, some side effects occur. So this study aim to focus on the side effects that may present among complete blood count parameters, such as red blood cell count, hemoglobin concentration, total whit blood count and related differential count of Neutrophil, Lymphocyte, and Monocyte. Beside Platelet count and related indices. Method Descriptive – cross sectional study conducted among 91 psychotic patients with epileptic episodes, set as case group and healthy individuals with no signs of anemia or infection set as control group to compare data with case group. Blood samples were collected in Ethylene Diamin Tetra Acetic Acid (EDTA) for complete blood count CBC, using automatic hematology analyzer Sysmex KX 21. Result Complete blood count parameters of case group and control group when compared with each other, revealed that significant difference (p value ≤ 0.05) in RBC, Hb and PCV as they were increased among case group than control group (the means of RBCs were 4.78±0.49 , 4.44±060V and Hb 13.29±1.78g/dl, 12.68±2.14g/dl and PCV 42.38± 5.45%, 38.28±6.92%), while platelet count was decreased among case group than control (mean ± SD = 208.09± 100.99 , 275.12±101.70 ). group (p value ≤ 0.05), with difference (p value ≤ 0.05) obtained through independent T test. Dose of drug and duration of taking did not give significant difference (p value ˃ 0.05). Conclusion Anti-epileptic drug, valporic acid has an effect on some of complete blood count parameters, such as platelet count, regardless the duration of medication and gender of patients.VI