Evaluation of Haemostatic Changes Among Non Complicated pregnancy in Shendi Locality - Nile River State - Sudan

Abstract

Acknowledgments: First of all I would like thank Allah, for giving me health strength and patience to complete this work. I would like to formally thank: My supervisor Dr. Umm Kulthum, hematology Department, Medical Laboratory Science, University of Shendi, for her invaluable advice, constructive criticism, continuous guidance, encouragement and patience throughout this study. Deep thanks to colleagues for their unlimited support and strong advice throughout this study. Also deep thanks to lab staff of Al Mek Nemir hospital and Shendi Teaching Hospital for their support. Special thanks to those helped me in practical part of this study A / Hamza, Ibrahim Issa, Khaled Saeed, Mahmoud Kabbashi, Badr al-Din Abdel-Mak, Zeinab Abdul Rahim, Salma Abdullah. My grateful thanks are extended to my best friend Nizar Al-Sasser. Last, but not least I would like to thank all my friends.5 Abstract: Background: Normal pregnancy is associated with haemostatic changes which have been linked to a complex physiological adaptation but these changes return to that of non-pregnant state at about 4 weeks of post-delivery. The study aimed to assess the PT,PTT, Fibrinogen and D-Dimer level among pregnant women .Methodology: This was a cross-sectional descriptive study, has been conducted at Mek Nemir hospital and Shendi Teaching Hospital from August 2015 to August 2017, Following informed consent 145 pregnant women in different trimesters and different ages were enrolled in this study, their aged ranged from (17- 40) years with mean average of SPSS version ---was used to calculate the mean , STD, frequency and independent t test , the p values were considered to be significant < (0.05) Results: The mean age of pregnant women was (24.4) years. Pregnant women with Haemostasis change in different trimesters 60% were in third trimester. In the study population the values of PT (14.3 ) second during pregnancy and control (12.5) second showed significant differences (P>0.00) but within normal range, values of APPT (34.1) second during pregnancy and control (32.4) second showed no significant differences (P=0.30), fibrinogen levels during pregnancy (548.1)mg/dl and control (269.6) mg/dl showed significant differences (P>0.00), and D-Dimer levels during pregnancy (609.7)ng/ml and control (285.5) ng/ml showed significant differences (P>0.00) without normal range. Conclusion: The study concluded that changed values of PT, APTT, fibrinogen levels and D-Dimer levels during pregnancy, It is recommended that fibrinogen level and D-Dimer level be monitored during pregnancy to minimize thrombotic effect.6