ASSOCIATION OF SERUM AUTO-ANTIBODIES AND THYROID FUNCTION TEST IN PATIENTS WITH NON-NEOPLASTIC THYROID DISEASES IN SHENDI LOCALITY, SUDAN

Abstract

Background: Thyroid disorders are the most second endocrine problem after diabetes mellitus in society. Environmental, immunological, and genetic factors lead to the development of thyroid disorders. Objectives: The study intended to evaluate the role of thyroid antibodies and hormones in the diagnosis of thyroid diseases, as well as the prevalence of thyroid antibodies in patients having thyroid disorders living in Shendi locality. Study design: The current research was prospective, case - control, hospital-based study carried out from 2013-2017, in El-Mek Nimir Uiversity Hospital in Shendi town- Northern Sudan.-. River Nile State. Two hundred and eighty-three (283) participants selected randomly as study population, of whom Hundred and eleven (111) patients with hypothyroidism; Seventy-two (72) patients with hyperthyroidism; Hundred (100) healthy normal subjects as control group. Participants were recruited from outpatient clinics in El-Mek Nimir Uiversity Hospital in Shendi Thyroid hormones profile (TSH, T4, T3, fT3, and fT4) and Thyroid antibodies (Anti-thyroid peroxidase and antithyroglobulin) were measured. Results: The study revealed that (60.7%) had hypothyroidism, (39.3%) had hyperthyroidism, (91.9%) of hypothyroidism were female, and only (8.1%) were male, while (84.7%) of hyperthyroidism were female while male represented only (15.3%) of them. The current study revealed that 107 of the case group (58.5%) were positive when evaluated for thyroid peroxidase antibodies (TPO Ab), with level more than (40.0 IU/ml). 72 (64.9%) of them were hypothyroidism, whereas a 35 (48.6%) of them were hyperthyroidism. As regard Thyroglobulin antibodies (Tg Ab), 73 (39.9%) of the case studied were positive, 51 (69.9%) of them were hypothyroidism, and 22 (30.1%) of them were hyperthyroidism. The study also revealed statistically significant positive correlation between the presence of TPO Ab and the values of fT3.