HPV Infection in Esophageal Squamous Cell Carcinoma

Abstract

Carcinomas of esophagus, mostly squamous cell carcinomas, occur throughout the world. There are a number of suspected genetic or environmental etiologies. Oncogenic human papillomavirus (HPV) has been hypothesized as a risk factor for esophageal squamous cell carcinoma. The aims of this review was to estimate the present of HPV by immunohistochemical technique Material and Methods: In this is descriptive retrospective study, which carried out Khartoum state -Sudan, formalin fixed paraffin embedded blocks from 30 patients previously diagnosed as esophageal tumors , Five (4) micron was taken on positively coated slide for immunohistochemical detection of HPV (6, 11, 16, 18, 31, 33, 42, 51, 52, 56 and 58). SPSS version 11.5 computer programs were used to analyze the data, frequencies, and means, the P.value was calculated by Chi square test. Result: The study involved (30) , 13 out of 30 were males (43.3%) and 17(55.7%) were females with (1.3:1) female: males ratio, their age ranging from 25 and 89 years with mean of age about 55.7 years old. HPV was detected in four samples (13.3%) with statistically insignificant difference between HPV infection and type of tumors. Conclusion: . This study demonstrates that the HPV infection rate in ESCC samples is very low, suggesting that HPV is not the etiological cause of ESCC in Sudan.