FREQUENCY OF RED BLOOD CELLS ALLOIMMUNIZATION AMONG MULTIGRAVIDA WOMEN

Abstract

Background Alloimmunization can describe as an immune response to exposure to antigens from another individual which genetically different. Although alloimmunization is a natural event during pregnancy, frequently it is the undesirable outcome of a blood transfusion and/or transplant. Red blood cells alloantibodies can be produce after exposure to foreign RBC antigens during blood transfusion therapy or pregnancy.[1] Methods: This descriptive analytical prospective cross sectional study was conducted in Shendi hospital, and aimed to detect the presence of irregular antibody in multigravida women. The patient's serum was tested for the presence of clinically significant antibodies using an indirect antiglobulin method. The serum was tested against un pooled Group O cells selected to possess the relevant blood group antigens. Results: The results revealed that alloantibodies were detected in one multigravida women (1.7%). In this study there was no correlation between ages, number of pregnancies and alloimmunization with (P.value=0.601 and 0.818)respectively. Current study revealed that significant correlation between history of abortion and alloimmunization (P. value=0.037). Conclusion: The study conclude that the frequency of alloantibodies were found in 1.7% of all pregnant women participated this study, it founds that there was relationship between alloimmunization with history of abortion, also it showed that there was no association between alloimmunization and age, number of pregnancy and stage of pregnancy.