Abstract:
I
Acknowledgment
Thanks to ALLAH for giving me strength to achieve this research
though a tough community base, which reminded me to be grateful of
having well fair and full appreciation to that.
Thanks to Dr. Hussam for guiding and enlightening though the path of
this work
Thanks to who worked behind sense and never get enough thanks……..
Thanks to everyone who did not got mentioned, not intentionallyIV
Abstract
Background
Epilepsy, affecting 5-10 per 1000 population, is characterized by the
occurrence of at least two unprovoked seizures brought about by abnormal
discharge of cortical neurons. The lifetime risk of developing psychiatric
disorder with epilepsy is extremely high with such individuals having
greater psychiatric co-morbidity when compared to the general population.
Valporic acid is a drug used as mood stabilizer and ant convulsion episodes,
it has been given indifferent doses prescribed by the physician and most of
time as anti-psychological drugs used for life, some side effects occur. So
this study aim to focus on the side effects that may present among complete
blood count parameters, such as red blood cell count, hemoglobin
concentration, total whit blood count and related differential count of
Neutrophil, Lymphocyte, and Monocyte. Beside Platelet count and related
indices.
Method
Descriptive – cross sectional study conducted among 91 psychotic patients
with epileptic episodes, set as case group and healthy individuals with no
signs of anemia or infection set as control group to compare data with case
group. Blood samples were collected in Ethylene Diamin Tetra Acetic Acid
(EDTA) for complete blood count CBC, using automatic hematology
analyzer Sysmex KX 21.
Result
Complete blood count parameters of case group and control group when
compared with each other, revealed that significant difference (p value ≤
0.05) in RBC, Hb and PCV as they were increased among case group than
control group (the means of RBCs were 4.78±0.49 , 4.44±060V
and Hb 13.29±1.78g/dl, 12.68±2.14g/dl and PCV 42.38±
5.45%, 38.28±6.92%), while platelet count was decreased among case group
than control (mean ± SD = 208.09± 100.99 , 275.12±101.70
).
group (p value ≤ 0.05), with difference (p value ≤ 0.05) obtained through
independent T test. Dose of drug and duration of taking did not give
significant difference (p value ˃ 0.05).
Conclusion
Anti-epileptic drug, valporic acid has an effect on some of complete blood
count parameters, such as platelet count, regardless the duration of
medication and gender of patients.VI
